Authors: Michael Epstein, Pradeep Bekal Effective colonoscopy requires effective bowel preparation. For detection of polyps larger than 5mm, an ‘adequate’ segmental cleansing level has recently been defined as score 2 or higher on the Boston Bowel Preparation Scale (BBPS) [1]. The NOC

Authors: Michael Epstein, Lucy Clayton, Richard Ng Kwet Shing Introduction. Successful bowel cleansing is required for effective colonoscopy. Polyethylene glycol (PEG) –based bowel preparations are widely used for this, despite many still requiring high fluid volume intake. To avoid t

Authors: Michael Epstein, Pradeep Bekal; Richard Ng Kwet Shing Background: Effective colonoscopy requires successful bowel cleansing. Inadequate bowel cleansing may decrease diagnostic sensitivity, necessitate repeat procedures and potentially delay appropriate treatment. The increasi

William D. Chey, Brian E. Lacy, Brooks D. Cash, Michael Epstein, Syed M. Shah Background: There are no FDA-approved pharmaceutical agents for functional dyspepsia (FD). Previous trials suggested that a combination of caraway oil and peppermint oil (Lmenthol) may be effective for FD. T

Brooks D. Cash, Michael Epstein, Syed M. Shah Background: Among adult patients diagnosed with IBS, a significant proportion endorse a mixed bowel habit pattern. There is no approved therapy for IBS-M, and it remains an unmet medical need. In IBS, gut mucosal barrier dysfunction is lin

Brooks D. Cash, Michael Epstein, Syed M. Shah Background: There are high placebo response rates in IBS clinical trials. Recently, more restrictive outcome measures have been developed for IBS trials to distinguish between active treatment response and placebo response. However, a stri

Bertiger, Gerald2 ; Epstein, Michael3 ; Lu, Liang4 ; Kitamura, Mikiya5 ; Bradesi, Sylvie1 ; Seifu, Yodit1 ; Brogadir, Stuart1 INSTITUTIONS (ALL): Ferring Pharmaceuticals Inc., Parsippany, NJ, United States. Hillmont G.I., Flourtown, PA, United States. Digestive Disorders Associates, A

A CARAWAY OIL/MENTHOL COMBINATION IMPROVES FUNCTIONAL DYSPEPSIA (FD) SYMPTOMS WITHIN THE FIRST 24 HOURS: RESULTS OF A RANDOMIZED CONTROLLED TRIAL, WHICH ALLOWED USUAL FD TREATMENTS Brian E. Lacy, William D. Chey, Brooks D. Cash, Michael Epstein, Syed M. Shah Background: Functional dys

EFFICACY OF CARAWAY OIL/L-MENTHOL PLUS USUAL CARE VS PLACEBO PLUS USUAL CARE, IN FUNCTIONAL DYSPEPSIA PATIENTS WITH POST-PRANDIAL DISTRESS (PDS) OR EPIGASTRIC PAIN (EPS) SYNDROMES: RESULTS FROM A US RCT William D. Chey, Brian E. Lacy, Brooks D. Cash, Michael Epstein, Syed M. Shah Back

Objective: Evaluate the safety and efficacy of OBV/PTV/r + DSV with low-dose RBV (600 mg once daily) for 12 weeks in GT1a HCV-infected patients, naïve or experienced (with pegIFN/RBV), without cirrhosis and compare with the historical SVR12 rate for 3-DAA + full-dose, weight based RBV